Reliable color detection in difference lightings.

I am working on a project where I need to detect color of a particular region of the object. While It's very easy to get RGB value from the frame of a particular object. Results fluctuate a lot when lighting changes. Ie, from natural light to artificial ones. I am wondering if there is anything to eliminate minor lighting changes to get a reliable color detection. Things I have tried so far. 1. Tried converting RGB to YCrCy and try hist_equalization on Y part. 2. Converted from BGR to gray, hist_equalizarion and converted back to RGB. Any suggestions ? Thanks in advance.